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Causes are: (1) excessive secretion of adrenocorticotropic hormone (ACTH) from the pituitary gland, which may actually result from faulty release of corticotropin-releasing factor (CRF) from the hypothalamus or a functional tumor, usually corticotroph adenoma; (2) tumor of the adrenal cortex, causing hypersecretion of the glucocorticoids; (3) iatrogenic Cushing's syndrome resulting from excessive or prolonged administration of exogenous glucocorticoids; and in humans (4) ectopic production of ACTH by extrapituitary tumors.

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