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According to the Justice Department, Abbott admitted to setting up a “specialized sales force” that marketed Depakote in nursing homes to control agitation and aggression in aging patients with dementia, even though there was no evidence that it was safe and effective for such use.
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Although the brand can cause weight gain for some users and may lead to other few side effects, it has been beneficial for mood disorders, epilepsy and migraine as this medication contains the active ingredient Divalproex.
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Depakote ER-treated group was greater than 5% and was greater than that for placebo patients.
Alopecia does not appear to be dose related.
The plausibility of maternal toxicant exposure and nutritional status as contributing factors to the risk of autism spectrum disorders.
It took me a two to three weeks before I saw a big difference when I started on Depakote (I take the generic Divalproex).
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You should read all product information carefully before purchasing and if you suspect you have a medical problem, promptly consult your health-care professional.
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Selected from data included with permission and copyrighted by First Databank, Inc.
Lamictal, Welbutrin and lorazepam to help my condition.
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Do not double the dose to catch up.
Serious liver damage that can cause death, especially in children younger than 2 years old.
Talk to your doctor about the risks of taking valproic acid or of giving valproic acid to your child.
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In May 2010, researchers found that could be caused by using the drug as early as the first trimester, which means that by the time many women discover they are pregnant, it could be too late to get off the drug and avoid birth defects for their unborn child.
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If the cause of the fatty liver stops, the liver can usually repair itself.
It's also important to understand if he or she prefers that you stay on the Depakote brand or if you may switch to a generic substitute.
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In overdose situations, the fraction of drug not bound to protein is high and hemodialysis or tandem hemodialysis plus hemoperfusion may result in significant removal of drug.
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In some cases, evidence of injury -- such as learning disabilities in children -- may not be discovered until years after the mother's exposure to the drug.
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This alert is based on the final results of the Neurodevelopmental Effects of Antiepileptic Drugs (NEAD) study showing that children exposed to valproate products while their mothers were pregnant had decreased IQs at age 6 compared to children exposed to other anti-epileptic drugs (see Data Summary).
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Do not use any of the medication from the pack if any of the blisters are torn, broken, or do not contain tablets.
One study has suggested that 80% of women treated with valproic acid before the age of 20 have polycystic ovaries or hyperandrogenism.
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After I got off this drug I lost 160lbs.
However, since valproate may interact with these or other concurrently administered AEDs as well as other drugs (see Drug Interactions), periodic plasma concentration determinations of concomitant AEDs are recommended during the early course of therapy (see PRECAUTIONS - Drug Interactions).
While no Depakote recall has been issued, one Depakote birth defect class action lawsuit was filed in March 2011 in St.
Pregnancy Registry: If you become pregnant while taking Depakote, talk to your healthcare provider about registering with the North American Antiepileptic Drug Pregnancy Registry.
What are the most common side effects of Depakote?
The Udvalg for Kliniske Undersogeiser (UKU) Side Effect Rating Scale will be administered at base line and weekly for the remainder of the study to determine the medication side effect profiles.
If proper warnings had been provided, women who were planning to become pregnant or those not practicing birth control, could have taken a different anti-seizure medication during pregnancy, as not all epilepsy drugs have the same risk of birth defects as Depakote.
Generic divalproex sodium will have the same safety warnings as Depakote, including a Boxed Warning that cautions about the risk of liver damage (hepatotoxicity), including fatalities, and pancreatitis, or an inflamed pancreas, including fatal cases.
It tends to cause fewer GI side effects than Depakene, is absorbed more slowly, and has a somewhat longer half life (12 hours vs.
Through use of co-counsel and local attorneys, cases are reviewed nationwide, but are not accepted in every state.
If you have not yet filled your first prescription, please select estimated values.
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At first the medicine did its job, not perfect but at least no serious side affect that i could see.
Critical relationship between sodium valproate dose and human teratogenicity: results of the Australian register of anti-epileptic drugs in pregnancy.
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Depakote has been marketed in the United States since 1983 as a treatment for simple and complex absence seizures.
If I have a very stressful work day ahead, I take an additional 1 in the morning.
Depakote ER Consumer information is supplied by First Databank, Inc.
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When compared with the children of non-Depakote users, children who were exposed to Depakote in the womb typically scored lower in IQ tests and other measures of cognitive function.
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Odds ratios were also adjusted for the individual registry (registries with no entries for valproic acid exposure were excluded) in the comparison of exposure to valproic acid monotherapy with no exposure to antiepileptic drugs; there were too few controls to make this adjustment in other comparisons.
Two six-month pediatric studies were conducted to evaluate the long-term safety of Depakote ER for the indication of mania (292 patients aged 10 to 17 years).
Topamax soon wasn't enough so my doc tried Latuda and it didn't work.
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Or complete this form to have RLG review your case promptly and contact you to confidentially discuss the process of seeking compensation for medical bills, lost wages, pain and suffering, and other damages.
I've provided will be used only by AbbVie and its contracted third parties to contact me by mail, email, and phone with helpful information on my condition, DEPAKOTE and other AbbVie treatments, products and services.
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Birth defects after prenatal exposure to antiepileptic drugs.
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It is generally treated with a nutritionally balanced diet and niacin supplements.
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BUT NOTE: it is ONLY FDA approved for bipolar mania, NOT for bipolar depression.
Research indicated that birth defects were discovered in 20 percent of pregnant Depakote users.
USES: Carbamazepine is used to prevent and control seizures.
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Exploiting the fact that certain OBRA provisions did not yet apply to Depakote, Abbott sales representatives stated that by using Depakote, nursing homes could avoid the administrative burdens and costs of complying with OBRA.
He also of course was calling himself names and saying he wished he was dead and he hates me among other things.
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Can cause liver damage, so it's probably not safe if you already have liver problems.
Carbatrol (carbamazepine), and Lamictal (lamotrigine) reduce the effect of Depakote.
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One contributing factor is the nonlinear, concentration dependent protein binding of valproate which affects the clearance of the drug.
Talk to your doctor about the risks of taking lamotrigine or of giving lamotrigine to your child.
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Several clinical trials have confirmed its efficacy as a monotherapy, as an adjunct to and as an adjunct to hydralazine.
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And then there's the corporate integrity agreement, a 5-year pledge that Abbott's board and top executives will get involved in the company's compliance efforts.
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On July 10, 2008, an advisory panel was convened by the Food and Drug Administration (FDA) to review data that the FDA had previously collected from drug studies showing an association between many of the antiepileptic drugs (AEDs) and suicidal ideation and behavior, which together are called suicidality.
Stopping suddenly may cause a serious, life-threatening type of seizure.
This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
However, it did not help with mania mood swings.
Signs of a very bad reaction to the drug.
Sold by Abbott Laboratories, the drug comes in a variety of forms: Depacon injections (valproate sodium), Depakote, Depakote CP and Depakote ER (divalproex sodium) and Depakene and Stavzor (valproic acid).
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ANTIEPILEPTIC DRUGS, INCLUDING VALPROATE, SHOULD BE ADMINISTERED TO WOMEN OF CHILDBEARING POTENTIAL ONLY IF THEY ARE CLEARLY SHOWN TO BE ESSENTIAL IN THE MANAGEMENT OF THEIR MEDICAL CONDITION.
The evidence: Studies have shown a connection between tryptophan depletion and depressive symptoms (especially in women), but the evidence for the use of tryptophan supplements is thin.
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Abbott was named one of the 2014 Top 20 Employers by the journal Science and listed as a Top 10 company for women by Working Mother magazine and the National Association for Female Executives.
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PATIENT WHO HAD LOW FIBRINOGEN WHEN TAKING MULTIPLE ANTICONVULSANTS INCLUDING VALPROATE GAVE BIRTH TO AN INFANT WITH AFIBRINOGENEMIA WHO SUBSEQUENTLY DIED OF HEMORRHAGE.
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Serious skin reactions (such as Stevens-Johnson Syndrome and toxic epidermal necrolysis) have been reported with concomitant lamotrigine and valproate administration.
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Today I found out about Keppra from my doctor, and she recommended it for me for those reasons.
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Anti-seizure medications: Phenytoin (Dilantin) and valproic acid (Depakote) may cause niacin deficiency in some people.
Before using Depakote ER, a woman who can become pregnant should consider the fact that Depakote ER has been associated with birth defects, in particular, with spina bifida and other defects related to failure of the spinal canal to close normally.
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Anyway, I can't say enough about this drug and what it has done for me.
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Advise patient to immediately report signs and symptoms of liver dysfunction (such as malaise, weakness, lethargy, appetite loss, vomiting, or yellowing of skin or eyes), signs and symptoms of pancreatitis (such as abdominal pain, nausea, vomiting, loss of appetite), or suicidal behavior or ideation.
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Nicotine patches: Using nicotine patches with niacin may worsen or increase the risk of flushing associated with niacin.
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FDA and reported my experience, I would hate for anyone to go through that.
Abbott's first international affiliate was in London in 1907, and the company later added an affiliate in Montreal, Canada (Fact 21).
It may also be used for other conditions as determined by your doctor.
If the weight gain continues as it does not seem to be leveling off then not only will she be dealing with self esteem issues for the first time in life related to weight but her weight will become a new health issue itself.
Depakote can also cause birth defects.
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Many allege that Abbott Laboratories was negligent in their duty to protect the public from being harmed from Depakote.
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According to office-based physician survey data for 2012, 57% of all drug use mentions for valproic acid and derivative products in women of reproductive potential age were associated with diagnoses of episodic mood disorders, 10% for the diagnoses of schizophrenic disorders, 9% for migraine, and 9% for epilepsy and recurrent seizures.
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CASES HAVE BEEN REPORTED SHORTLY AFTER INITIAL USE AS WELL AS AFTER SEVERAL YEARS OF USE.
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Depakote ER 500 mg for 10 days now, or maybe I should say nights.
If you have any questions, consult your doctor or pharmacist.
Your doctor may start you on a low dose of valproic acid and gradually increase your dose.
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